Amikacin B Sulfate (Amikacin EP Impurity H Sulfate) CAS 48237-20-3(free base)

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.48237-20-3(free base)
Molecular FormulaC22H44N6O12
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Amikacin B Sulfate (Amikacin EP Impurity H Sulfate) CAS 48237-20-3(free base) chemical structure

Description

The occurrence of Amikacin B Sulfate (Amikacin EP Impurity H Sulfate) is closely related to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

As a process- or degradation-related impurity, Amikacin B Sulfate (Amikacin EP Impurity H Sulfate) (CAS 48237-20-3(free base), C22H44N6O12•xH2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

The molecular framework of Amikacin B Sulfate (Amikacin EP Impurity H Sulfate) (C22H44N6O12•xH2O4S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

CATO manufactures Amikacin B Sulfate (Amikacin EP Impurity H Sulfate) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC22H44N6O12 • xH2O4S
Molecular Weight682.70 g/mol
Purity>90%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
Nitrogen Atoms6
Sulfur Atoms1

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